Robert J, Laurens M H, Simeons P, Thouvenot P, Wayoff M
Pathol Biol (Paris). 1980 Mar;28(3):181-4.
The authors propose a method for the investigation of the muco-ciliary function of the nasal mucosa: they record the motion of radioactive particles, which are put by sonic nebulisation on nasal mucosa. The average speed is calculated by means of the analysis of sequential images and by the study of the variation of activity in relation to time in several main zones. A half-clearing time of the initial activity is also measured. The average speed is 8.33 mm/minute for normal persons and 2.36 mm/minute for a group of patients. This simple, accurate, non aggressive method is used for pharmacodynamic tests.
他们记录放射性颗粒的运动,这些颗粒通过超声雾化放置在鼻黏膜上。通过对连续图像的分析以及对几个主要区域活性随时间变化的研究来计算平均速度。还测量了初始活性的半清除时间。正常人的平均速度为8.33毫米/分钟,一组患者的平均速度为2.36毫米/分钟。这种简单、准确、无创的方法用于药效学测试。