Nuutinen J
Acta Otolaryngol. 1985 May-Jun;99(5-6):605-9. doi: 10.3109/00016488509182267.
The effect of HR-6 solution containing adenosine triphosphate 10 mg/ml on the impaired nasal mucocililary function in 13 patients was studied. The nasal mucociliary function measured with the radioisotopic method using 99Tc-labelled human serum albumin as a tracer substance was markedly impaired in all patients. The patients had had symptoms of upper and/or lower respiratory tract infections for 8 1/2 years, on the average. The nasal mucociliary function ranged from 0 to 5.0 mm/minute, mean 2.0 mm/minute. In this single dose study the test drug improved nasal mucociliary function by at least 1.4 mm/minute in 77% of the patients and by at least 2.8 mm/minute in 54% of the patients. This preliminary study indicates the need for further examinations with the HR-6 in patients with impaired mucociliary function.
研究了含10毫克/毫升三磷酸腺苷的HR-6溶液对13例鼻黏膜纤毛功能受损患者的影响。使用以99Tc标记的人血清白蛋白作为示踪物质的放射性同位素方法测量的鼻黏膜纤毛功能在所有患者中均明显受损。这些患者平均有8.5年的上呼吸道和/或下呼吸道感染症状。鼻黏膜纤毛功能范围为0至5.0毫米/分钟，平均为2.0毫米/分钟。在这项单剂量研究中，受试药物使77%的患者鼻黏膜纤毛功能至少提高了1.4毫米/分钟，54%的患者至少提高了2.8毫米/分钟。这项初步研究表明，需要对鼻黏膜纤毛功能受损的患者进一步使用HR-6进行检查。
