Marhaug G, Bratlid D, Moe P J
Scand J Infect Dis. 1980;12(1):61-5. doi: 10.3109/inf.1980.12.issue-1.11.
The effect of methotrexate on the phagocytosis and killing of Staphylococcus aureus by granulocytes from healthy blood donors was investigated in vitro. A concentration of methotrexate of 2.2 x 10(-4) mol/1 (100 micrograms/ml), which is readily obtained on high dose intravenous administration did not decrease the phagocytosis and intracellular killing of Staph. aureus. In addition, granulocytes isolated from patients after termination of 6 h and 24 h high-dose methotrexate infusions showed normal phagocytic activity.
体外研究了甲氨蝶呤对健康献血者粒细胞吞噬和杀灭金黄色葡萄球菌的影响。甲氨蝶呤浓度为2.2×10⁻⁴摩尔/升（100微克/毫升），这在大剂量静脉给药时很容易达到，该浓度并未降低金黄色葡萄球菌的吞噬作用和细胞内杀灭能力。此外，在大剂量甲氨蝶呤输注6小时和24小时结束后从患者体内分离出的粒细胞显示出正常的吞噬活性。
