丙磺舒对人单核细胞和粒细胞吞噬及细胞内杀灭金黄色葡萄球菌和大肠杆菌的影响。
Effect of probenecid on phagocytosis and intracellular killing of Staphylococcus aureus and Escherichia coli by human monocytes and granulocytes.
作者信息
Buisman H P, Buys L F, Langermans J A, van den Broek P J, van Furth R
机构信息
Department of Infectious Diseases, University Hospital, Leiden, The Netherlands.
出版信息
Immunology. 1991 Oct;74(2):338-41.
The present study concerns the effects of probenecid on the phagocytosis and intracellular killing of Staphylococcus aureus and Escherichia coli by human monocytes and granulocytes. In both monocytes and granulocytes the inhibitory effect on phagocytosis was very small. Inhibition of intracellular killing of S. aureus by monocytes and granulocytes by probenecid was concentration dependent, being half-maximal at about 2 mM probenecid, and near-maximal at about 5 mM probenecid. The intracellular killing could also be inhibited when probenecid was added when this process was already started. Probenecid also inhibited the intracellular killing of E. coli by granulocytes, but not by monocytes. In the concentration range used, probenecid had no toxic effect on phagocytes or bacteria during the 2 hr of the experiments.
本研究关注丙磺舒对人单核细胞和粒细胞吞噬及细胞内杀灭金黄色葡萄球菌和大肠杆菌的影响。在单核细胞和粒细胞中，丙磺舒对吞噬作用的抑制作用非常小。丙磺舒对单核细胞和粒细胞细胞内杀灭金黄色葡萄球菌的抑制作用呈浓度依赖性，在丙磺舒浓度约为2 mM时达到半数最大抑制浓度，在约5 mM时接近最大抑制浓度。当细胞内杀灭过程已经开始时加入丙磺舒，其也能抑制该过程。丙磺舒还能抑制粒细胞对大肠杆菌的细胞内杀灭，但对单核细胞无此作用。在所用的浓度范围内，在实验的2小时期间丙磺舒对吞噬细胞或细菌没有毒性作用。
Zotero 插件