Emery D, McCullagh P
Transplantation. 1980;29(1):10-16. doi: 10.1097/00007890-198001000-00003.
The response of normal single-born calves to the s.c. injection of allogeneic lymphocytes and that of chimeric calves to allogeneic and cotwin cells were studied. Whereas allogeneic cells produced local dermal swelling along with an efflux of blast cells and specific cytolytic antibody in the regional lymph, the injection of cotwin lymphocytes into chimeric calves failed to produce responses in excess of those of controls. There was little indication of specific reduction in responsiveness of the lymphocytes of normal calves following challenge with allogeneic cells.
研究了正常单胎出生犊牛对皮下注射同种异体淋巴细胞的反应以及嵌合体犊牛对同种异体和同卵双生细胞的反应。虽然同种异体细胞会引起局部皮肤肿胀，同时伴有母细胞外流和局部淋巴结中特异性溶细胞抗体的产生，但向嵌合体犊牛注射同卵双生淋巴细胞所产生的反应并未超过对照组。几乎没有迹象表明正常犊牛的淋巴细胞在用同种异体细胞攻击后反应性有特异性降低。
