Kim J C, Elkin D, Hendrickson F R
Cancer. 1978 Sep;42(3):1114-9. doi: 10.1002/1097-0142(197809)42:3<1114::aid-cncr2820420312>3.0.co;2-3.
A retrospective analysis has been done of 173 patients with epidermoid carcinoma of the vocal cord treated with radiation therapy at Rush-Presbyterian-St. Luke's Medical Center between January 1970 and December )974. one hundred fifty-eight patients (91.3%) were early (T1, T2) glottic lesion and 10 were advanced (T3, T4) lesion. Five (2.9%) were presented with positive cervical lymph nodes initially. Of 158 patients who had T1, T2N0M0 glottic tumor, 146 had definitive radiation therapy and 12 had preoperative radiation therapy. An analysis of frequency of local recurrence versus total dose (NSD) has been done for 146 patients and a dose response curve has been generated. Local failure rates were 22.2% for 1,800 +/- 50 rets, 11.1% for 1,900 +/- 50 rets, and 3.2% for 2,000 +/- 50 rets. For the early glottic cancer, local control rates were increased with increasing total dose without significant complications. In patients with advanced primary tumors, a greater number of the patients were treated with preoperative radiation therapy and this group had slightly better results.
对1970年1月至1974年12月期间在拉什-长老会-圣卢克医疗中心接受放射治疗的173例声带表皮样癌患者进行了回顾性分析。158例（91.3%）为早期（T1、T2）声门病变，10例为晚期（T3、T4）病变。5例（2.9%）初诊时伴有颈部淋巴结阳性。在158例T1、T2N0M0声门肿瘤患者中，146例接受了根治性放射治疗，12例接受了术前放射治疗。对146例患者进行了局部复发频率与总剂量（NSD）的分析，并绘制了剂量反应曲线。1800±50rets时局部失败率为22.2%，1900±50rets时为11.1%，2000±50rets时为3.2%。对于早期声门癌，随着总剂量增加局部控制率提高，且无明显并发症。对于晚期原发性肿瘤患者，更多患者接受了术前放射治疗，该组结果略好。
