Karim A B, Snow G B, Hasman A, Chang S C, Keilholtz A, Hoekstra F
Cancer. 1978 May;41(5):1728-32. doi: 10.1002/1097-0142(197805)41:5<1728::aid-cncr2820410512>3.0.co;2-h.
All consecutive patients with glottic squamous cell carcinoma treated primarily by radiotherapy from 1965 through 1974 have been analyzed to reveal response of the primary tumor in relation to the dose. This study appears to indicate presence of dose response for all stages of the primary lesions (T) of the glottic carcinoma except for the smallest ones namely TIS, T1a and T1b. The total number of advanced tumors is small and selected. But they tend to indicate presence of dose response. Out of 15 selected patients with T3 and T4 glottic tumors, 5 (33%) had attained local control by primary radiotherapy; two had distant metastasis at onset of therapy, while 5 (33%) needed salvage surgery for control of the residual or recurrent disease. The ultimate success rate is 66% (10 out of 15) for the patients with advanced tumors treated with a conservative approach. An ongoing study indicates similar, if not better preliminary results with high dose radiotherapy.
对1965年至1974年间主要接受放射治疗的所有连续性声门鳞状细胞癌患者进行了分析，以揭示原发肿瘤对剂量的反应。本研究似乎表明，除了最小的病变阶段即Tis、T1a和T1b外，声门癌原发病变（T）的所有阶段均存在剂量反应。晚期肿瘤的总数较少且经过筛选。但它们倾向于表明存在剂量反应。在15例经筛选的T3和T4期声门肿瘤患者中，5例（33%）通过原发放射治疗获得了局部控制；2例在治疗开始时发生远处转移，而5例（33%）需要挽救性手术来控制残留或复发性疾病。采用保守方法治疗的晚期肿瘤患者的最终成功率为66%（15例中的10例）。一项正在进行的研究表明，高剂量放射治疗的初步结果即使不更好，也相似。
