Shelepov V P, Davydova S Ia, Shapot V S
Vopr Med Khim. 1980 Jan-Feb;26(1):105-10.
In tumor-bearing rats the hematocrit volume was decreased. It is recommended therefore to estimate the content of glucose in blood serum but not in the whole blood. In rats with Zajhdela ascites hepatoma and with solid hepatoma 27 contents of insulin and glucagon in blood and of glycogen in liver were altered. The nature and magnitude of these alterations varied depending on the type of the transplated tumor. The hormonal disbalance appears to be due to loss of receptor sensitivity towards these hormones. In blood serum of healthy and tumor-bearing rats maximal glucose content was observed within 30 min after sugar loading, after which the content of glucose in blood serum was decreased. In the tumor-bearing rats the increase in content of glucose after sugar loading was higher than in the healthy animals, and the return of content of glucose to normal values was considerably delayed in the tumor-bearing rats. Apparent Vass for glucose was distinctly lower in healthy as compared with tumor-bearing animals. Simultaneous increase in content of glucose and insulin was found in blood serum of healthy rats after sugar loading, whereas the increase in insulin content was retarded in the tumor-bearing animals.
在荷瘤大鼠中，血细胞比容降低。因此建议测定血清而非全血中的葡萄糖含量。在患有扎伊德赫拉腹水肝癌和实体肝癌27的大鼠中，血液中胰岛素和胰高血糖素的含量以及肝脏中糖原的含量发生了改变。这些改变的性质和程度因移植肿瘤的类型而异。激素失衡似乎是由于受体对这些激素的敏感性丧失所致。在健康大鼠和荷瘤大鼠的血清中，糖负荷后30分钟内观察到最大葡萄糖含量，此后血清中葡萄糖含量降低。荷瘤大鼠糖负荷后葡萄糖含量的增加高于健康动物，且荷瘤大鼠中葡萄糖含量恢复到正常水平的时间明显延迟。与荷瘤动物相比，健康动物中葡萄糖的表观清除率明显较低。糖负荷后，健康大鼠血清中葡萄糖和胰岛素含量同时增加，而荷瘤动物中胰岛素含量的增加则延迟。
