Kozlov Iu A, Lavrova V S
Vopr Onkol. 1980;26(2):46-9.
Observations were carried out in rats with transplantable Geren's carcinoma or sarcoma induced by 3,4-benz (a) pyrene. The contents of plasma immune-reactive insulin (IRI), the glucose tolerance and response of the insular apparatus to the glycemia level were found to change at all stages of the tumor growth. Most of animals had low levels of IRI in blood, the glucose tolerance was decreased. Some rats with Geren's carcinoma showed the signs of increased functioning of the insular apparatus. It was shown that disorders in the insular apparatus function in tumor-bearing animals were due to changing of its response to the level of glycemia.
对移植了可移植性格林氏癌或由3,4-苯并(a)芘诱导的肉瘤的大鼠进行了观察。发现在肿瘤生长的各个阶段，血浆免疫反应性胰岛素（IRI）的含量、葡萄糖耐量以及胰岛对血糖水平的反应均发生了变化。大多数动物血液中的IRI水平较低，葡萄糖耐量降低。一些患有格林氏癌的大鼠表现出胰岛功能增强的迹象。结果表明，荷瘤动物胰岛功能障碍是由于其对血糖水平反应的改变所致。
