Yetgin S, Gur A, Saatci U
Acta Paediatr Scand. 1980 Jan;69(1):21-4. doi: 10.1111/j.1651-2227.1980.tb07023.x.
In order to explain susceptibility to bacterial infection in patients with nephrotic syndrome, bactericidal capacity of polymorphonuclear neutrophils (PMN) and serum opsonic activity were studied. The groups consisted of 29 patients and 29 controls. Bactericidal capacity was found to be statistically significant defective in the patient group when compared with controls for Staphylococcus aureus and Excherichia coli. Serum opsinic activity was found to be defective in up to 50% of the patients, but it was not statistically significant for either bacteria. There is no correlation between the impairment of bactericidal capacity and serum total protein, albumin, globulin, total lipid, cholesterol, age of patients and the duration of the illness. When bactericidal capacity was examined in five patients in remission it had returned to the normal level. The results of this study suggest that bactericidal capacity and possibly serum opsonic activity are influenced by the nephrotic syndrome.
为了解释肾病综合征患者易发生细菌感染的原因，我们研究了多形核中性粒细胞（PMN）的杀菌能力和血清调理活性。研究对象分为29例患者和29例对照。与对照组相比，患者组对金黄色葡萄球菌和大肠杆菌的杀菌能力存在统计学上的显著缺陷。高达50%的患者血清调理活性存在缺陷，但对两种细菌而言，差异均无统计学意义。杀菌能力受损与血清总蛋白、白蛋白、球蛋白、总脂质、胆固醇、患者年龄及病程之间均无相关性。对5例缓解期患者的杀菌能力进行检测时，其已恢复至正常水平。本研究结果提示，肾病综合征会影响杀菌能力，可能还会影响血清调理活性。
