青霉胺性天疱疮患者的免疫组化结果

Immunohistochemical findings in a patient with penicillamine pemphigus.

作者信息

de Jong M C, Doeglas H M, Dijkstra J W

出版信息

Br J Dermatol. 1980 Mar;102(3):333-7. doi: 10.1111/j.1365-2133.1980.tb08149.x.

DOI:10.1111/j.1365-2133.1980.tb08149.x

Abstract

This report describes the immunofluorescence (IF) findings in sequential skin biopsies and serum obtained during a follow-up study of a patient who developed pemphigus lesions after D-penicillamine treatment of arthritis. The distribution in the skin of IgG, IgM and C3 varied with the date, type and site of the biopsy sample. Thus IF patterns showed features of (a) pemphigus vulgaris, (b) pemphigus foliaceus and (c) pemphigus erythematosus. Indirect IF examination indicated the presence of circulating intercellular epithelial antibody of both the IgG and IgM class.

摘要

本报告描述了一名关节炎患者在接受D-青霉胺治疗后出现天疱疮皮损，在后续研究中对其进行的连续皮肤活检及血清样本的免疫荧光（IF）检查结果。皮肤中IgG、IgM和C3的分布随活检样本的日期、类型及部位而变化。因此，免疫荧光模式呈现出（a）寻常型天疱疮、（b）落叶型天疱疮和（c）红斑型天疱疮的特征。间接免疫荧光检查显示存在IgG和IgM类循环细胞间上皮抗体。