Barnett H J, Gent M, Sackett D L, Taylor D W
Can Med Assoc J. 1980 Mar 8;122(5):535-40.
Transient cerebral ischemia and stroke may occur despite previous occlusion of the artery supplying the appropriate part of the brain. After occlusion of the internal carotid artery, emboli may pass from the "stump" of the occluded artery to later produce transient cerebral ischemia or a stroke. Transient cerebral ischemia and stroke are due to a variety of conditions, some of which are strongly correlated with platelet thromboembolism, while others have little primary relation to thrombosis. The impact of this on therapeutic considerations is obvious. Thromboembolism related to myxomatous degeneration of the mitral valve (mitral valve prolapse) is a factor to consider in determining the cause of a stroke in a younger person. The prognosis for the different varieties of threatened stroke is incompletely known. When due to arteriosclerosis of the large cerebral arteries, transient cerebral ischemia and minor strokes pose a cumulative threat for a major stroke or death of 13% in the first year, 22% in the second year and 30% in the third year.
尽管先前供应大脑相应部位的动脉已闭塞，但仍可能发生短暂性脑缺血和中风。颈内动脉闭塞后，栓子可能从闭塞动脉的“残端”脱落，随后导致短暂性脑缺血或中风。短暂性脑缺血和中风由多种情况引起，其中一些与血小板血栓栓塞密切相关，而另一些与血栓形成几乎没有直接关系。这对治疗考虑的影响显而易见。二尖瓣黏液样变性（二尖瓣脱垂）相关的血栓栓塞是确定年轻人中风病因时需要考虑的一个因素。不同类型的先兆性中风的预后尚不完全清楚。当由大脑大动脉的动脉硬化引起时，短暂性脑缺血和轻度中风在第一年发生重大中风或死亡的累积风险为13%，第二年为22%，第三年为30%。
