Watkins W B, Moore R Y, Burton D, Bone H G, Catherwood B D, Deftos L J
Endocrinology. 1980 Jun;106(6):1966-70. doi: 10.1210/endo-106-6-1966.
Immunohistochemical (immunoperoxidase) studies were performed on 478 sections from 97 rat pituitary glands with rabbit antisera to unconjugated human synthetic calcitonin beta-endorphin, and/or ACTH-(17--39). Calcitonin-positive cells were present in a majority of the anterior lobes studied, whereas they were present in only a minority of the intermediate lobes. Calcitonin-positive cells were also present in chronically thyroidectomized animals. Beta-Endorphin-positive cells were uniformly present in the intermediate lobes as were the ACTH-positive cells. In the anterior pituitary lobes, beta-endorphin-positive cells were more populous than the ACTH-positive cells, and in general, there was a dissociation of the cellular elements containing beta-endorphin, ACTH, and calcitonin. Although it remains possible that there is calcitonin-like immunoreactivity within a precursor molecule that is differentially processed by pituitary cells, these studies are more consistent with the view that immunoreactive calcitonin is present in pituitary cells which are not as yet precisely and consistently related to any identifiable population of hormone-producing cells.
用兔抗未结合的人合成降钙素、β-内啡肽和/或促肾上腺皮质激素（17 - 39）抗血清，对97个大鼠垂体的478个切片进行了免疫组织化学（免疫过氧化物酶）研究。在所研究的大多数前叶中存在降钙素阳性细胞，而在中间叶中仅少数存在。降钙素阳性细胞在长期甲状腺切除的动物中也存在。β-内啡肽阳性细胞与促肾上腺皮质激素阳性细胞一样，均存在于中间叶。在前垂体叶中，β-内啡肽阳性细胞比促肾上腺皮质激素阳性细胞更多，并且一般而言，含有β-内啡肽、促肾上腺皮质激素和降钙素的细胞成分存在分离现象。尽管垂体细胞对前体分子进行差异加工时，前体分子内仍可能存在降钙素样免疫反应性，但这些研究更符合以下观点：免疫反应性降钙素存在于垂体细胞中，这些细胞与任何可识别的激素产生细胞群体尚未精确且一致地相关。
