Nygren A, Sundblad L
Diabetologia. 1980 Mar;18(3):193-5. doi: 10.1007/BF00251915.
The effect of alpha-adrenergic stimulation by IV adrenaline and propranolol infusion upon basal insulin and growth hormone secretion was studied in six chronic alcoholics during alcohol withdrawal, two alcoholics recently admitted to hospital with alcohol-induced hypoglycaemia and twelve healthy subjects. In all healthy subjects a decline in basal insulin (mean +/- SEM decremental area 166 +/- 19) and an increase in growth hormone (mean +/- SEM incremental area 527 +/- 164) was found. In the two alcoholics admitted to hospital with alcohol hypoglycaemia, no consistent change occurred in basal insulin and basal growth hormone concentrations during alpha-adrenergic stimulation. In the other alcoholics a decrease in basal insulin (mean +/- SEM decremental area 91 +/- 13.5) was found, but this decrease was significantly less (p less than 0.05) than in healthy subjects. Growth hormone did not change significantly in these alcoholics. It is concluded that disturbances in the alpha-adrenergic modulation of basal insulin and growth hormone secretions are common in alcoholics in a withdrawal state. The implication of this finding for the occurrence of alcohol-induced hypoglycaemic coma is discussed.
在六名戒酒期的慢性酒精中毒者、两名因酒精性低血糖症近期入院的酗酒者以及十二名健康受试者中，研究了静脉注射肾上腺素和输注普萘洛尔对基础胰岛素和生长激素分泌的α-肾上腺素能刺激作用。在所有健康受试者中，发现基础胰岛素下降（平均±标准误减量面积166±19），生长激素增加（平均±标准误增量面积527±164）。在两名因酒精性低血糖症入院的酗酒者中，α-肾上腺素能刺激期间基础胰岛素和基础生长激素浓度未出现一致变化。在其他酗酒者中，发现基础胰岛素下降（平均±标准误减量面积91±13.5），但这种下降明显小于健康受试者（p<0.05）。这些酗酒者的生长激素没有明显变化。得出的结论是，在戒酒状态的酗酒者中，基础胰岛素和生长激素分泌的α-肾上腺素能调节紊乱很常见。讨论了这一发现对酒精性低血糖昏迷发生的影响。
