Sieber G, Rühl H
Immunobiology. 1980 Jan;156(4-5):464-9. doi: 10.1016/S0171-2985(80)80079-9.
Ribosomal 30S and 50S subunits as well as total proteins from the large subunit of E. coli ribosomes were found to be potent mitogens for both human adult and cord blood lymphocytes. On the other hand, the RNA fraction of the 50S subunit had only a weak stimulatory capacity suggesting that the protein moiety contains the stimulatory component. Experiments with lymphocyte subpopulations obtained by nylon wool filtration of E-rosette separation have shown that, in human, the main target cells are T lymphocytes. First experiments with mouse spleen cells indicate that, in mice, T and B lymphocytes can be stimulated by ribosomal proteins.
核糖体30S和50S亚基以及大肠杆菌核糖体大亚基的总蛋白被发现是人类成人和脐带血淋巴细胞的有效促有丝分裂原。另一方面，50S亚基的RNA部分只有微弱的刺激能力，这表明蛋白质部分含有刺激成分。通过尼龙毛过滤或E花环分离获得的淋巴细胞亚群实验表明，在人类中，主要靶细胞是T淋巴细胞。对小鼠脾细胞的初步实验表明，在小鼠中，T淋巴细胞和B淋巴细胞都可以被核糖体蛋白刺激。
