亚硝酸对双链脱氧核糖核酸的损伤：胞嘧啶残基脱氨基作用与一种新型突变损伤之间的区别。
Nitrous acid damage to duplex deoxyribonucleic acid: distinction between deamination of cytosine residues and a novel mutational lesion.
作者信息
Frankel A D, Duncan B K, Hartman P E
出版信息
J Bacteriol. 1980 Apr;142(1):335-8. doi: 10.1128/jb.142.1.335-338.1980.
Abstract
The rate of nitrous acid deamination of labeled cytosine residues in native Escherichia coli deoxyribonucleic acid was monitored in vitro by release of acid-soluble counts after treatment with uracil deoxyribonucleic acid glycosylase. The reaction exhibited a lag and was not stimulate by several agents previously shown to enhance base substitution mutagenesis during nitrous acid treatment of duplex deoxyribonucleic acid. We conclude that a significant proportion of nitrous acid induced mutagenic lesions are novel lesions and not cytosine deaminations.
摘要
通过用尿嘧啶脱氧核糖核酸糖基化酶处理后释放的酸溶性计数，在体外监测天然大肠杆菌脱氧核糖核酸中标记的胞嘧啶残基的亚硝酸脱氨基速率。该反应表现出滞后现象，并且不受先前显示在亚硝酸处理双链脱氧核糖核酸期间增强碱基取代诱变的几种试剂的刺激。我们得出结论，亚硝酸诱导的诱变损伤的很大一部分是新的损伤，而不是胞嘧啶脱氨基。
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