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1
Nitrous acid damage to duplex deoxyribonucleic acid: distinction between deamination of cytosine residues and a novel mutational lesion.亚硝酸对双链脱氧核糖核酸的损伤：胞嘧啶残基脱氨基作用与一种新型突变损伤之间的区别。
J Bacteriol. 1980 Apr;142(1):335-8. doi: 10.1128/jb.142.1.335-338.1980.
2
Repair of nitrous acid damage to DNA in Escherichia coli.大肠杆菌中DNA亚硝酸损伤的修复
Biochemistry. 1977 Nov 1;16(22):4934-9. doi: 10.1021/bi00641a030.
3
Nitrous acid mutagenesis of duplex DNA as a three-component system.作为三元系统的双链DNA亚硝酸诱变
Mutat Res. 1979 Jul;61(2):129-51. doi: 10.1016/0027-5107(79)90121-0.
4
Molecular models that may account for nitrous acid mutagenesis in organisms containing double-stranded DNA.可能解释含双链DNA生物体中亚硝酸诱变作用的分子模型。
Environ Mol Mutagen. 1994;24(3):168-75. doi: 10.1002/em.2850240305.
5
Cytosine deaminations catalyzed by DNA cytosine methyltransferases are unlikely to be the major cause of mutational hot spots at sites of cytosine methylation in Escherichia coli.由DNA胞嘧啶甲基转移酶催化的胞嘧啶脱氨基作用不太可能是大肠杆菌中胞嘧啶甲基化位点突变热点的主要原因。
Proc Natl Acad Sci U S A. 1994 Feb 15;91(4):1574-8. doi: 10.1073/pnas.91.4.1574.
6
Endonuclease V protects Escherichia coli against specific mutations caused by nitrous acid.核酸内切酶V保护大肠杆菌免受亚硝酸引起的特定突变的影响。
Mutat Res. 1999 Dec 7;435(3):245-54. doi: 10.1016/s0921-8777(99)00049-x.
7
Heat-induced deamination of cytosine residues in deoxyribonucleic acid.脱氧核糖核酸中胞嘧啶残基的热诱导脱氨基作用。
Biochemistry. 1974 Jul 30;13(16):3405-10. doi: 10.1021/bi00713a035.
8
Effect of DNA cytosine methylation upon deamination-induced mutagenesis in a natural target sequence in duplex DNA.DNA胞嘧啶甲基化对双链DNA天然靶序列中脱氨基诱导诱变的影响。
J Biol Chem. 1994 Mar 11;269(10):7066-9.
9
Relative contribution of cytosine deamination and error-prone replication to the induction of propanodeoxyguanosine-->deoxyadenosine mutations in Escherichia coli.胞嘧啶脱氨基作用和易错复制对大肠杆菌中1-丙基脱氧鸟苷→脱氧腺苷突变诱导的相对贡献
Chem Res Toxicol. 1996 Jan-Feb;9(1):277-83. doi: 10.1021/tx950060w.
10
Nitrous acid reactivation of ultraviolet-irradiated denatured transforming DNA.亚硝酸对紫外线照射变性的转化DNA的复活作用
Photochem Photobiol. 1987 Jan;45(1):145-6. doi: 10.1111/j.1751-1097.1987.tb08415.x.

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Aryl diazonium intermediates enable mild DNA-compatible C-C bond formation for medicinally relevant combinatorial library synthesis.芳基重氮中间体能够实现温和的与DNA兼容的C-C键形成，用于药物相关组合库的合成。
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Dynamics of Mismatch and Alternative Excision-Dependent Repair in Replicating DNA Examined Under Conditions of Neutral Selection.在中性选择条件下检测复制DNA中错配与替代切除依赖修复的动力学
Front Microbiol. 2022 Jun 30;13:866089. doi: 10.3389/fmicb.2022.866089. eCollection 2022.
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New Insights into the Structure and Reactivity of Uracil Derivatives in Different Solvents-A Computational Study.不同溶剂中尿嘧啶衍生物的结构与反应活性新见解——一项计算研究
ACS Omega. 2020 Aug 24;5(35):22449-22458. doi: 10.1021/acsomega.0c02943. eCollection 2020 Sep 8.
6
Repair activity of base and nucleotide excision repair enzymes for guanine lesions induced by nitrosative stress.亚硝化应激诱导的鸟嘌呤损伤的碱基和核苷酸切除修复酶的修复活性。
Nucleic Acids Res. 2005 Apr 14;33(7):2181-91. doi: 10.1093/nar/gki513. Print 2005.
7
Identification of a copper-responsive two-component system on the chromosome of Escherichia coli K-12.在大肠杆菌K-12染色体上鉴定出一个铜响应双组分系统。
J Bacteriol. 2000 Oct;182(20):5864-71. doi: 10.1128/JB.182.20.5864-5871.2000.
8
Interaction of mutagenic spermidine-nitrous acid reaction products with uvr- and recA-dependent repair systems in Salmonella.鼠伤寒沙门氏菌中诱变亚精胺-亚硝酸反应产物与uvr和recA依赖性修复系统的相互作用
J Bacteriol. 1980 Apr;142(1):191-5. doi: 10.1128/jb.142.1.191-195.1980.
9
Role of exonuclease III in the base excision repair of uracil-containing DNA.核酸外切酶III在含尿嘧啶DNA碱基切除修复中的作用。
J Bacteriol. 1982 Jul;151(1):351-7. doi: 10.1128/jb.151.1.351-357.1982.
10
Method for induction of mutations in physically defined regions of the herpes simplex virus genome.在单纯疱疹病毒基因组物理定义区域诱导突变的方法。
J Virol. 1981 Apr;38(1):41-9. doi: 10.1128/JVI.38.1.41-49.1981.

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IDENTIFICATION OF THE ALTERED BASES IN MUTATED SINGLE-STRANDED DNA. I. IN VITRO MUTAGENESIS BY HYDROXYLAMINE, ETHYL METHANESULFONATE AND NITROUS ACID.突变单链DNA中碱基改变的鉴定。I. 羟胺、甲基磺酸乙酯和亚硝酸的体外诱变作用
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EFFECTS OF NITROUS ACID ON THE DAT COPOLYMER AS A TEMPLATE FOR DNA POLYMERASE.亚硝酸对作为DNA聚合酶模板的脱氧核糖核酸-蛋白质复合物的影响
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STRUCTURE AND FUNCTION OF CROSS-LINKED DNA. I. REVERSIBLE DENATURATION AND BACILLUS SUBTILIS TRANSFORMATION.交联DNA的结构与功能。I. 可逆变性与枯草芽孢杆菌转化
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Acetylornithinase of Escherichia coli: partial purification and some properties.大肠杆菌的乙酰鸟氨酸酶：部分纯化及某些性质
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Interaction of mutagenic spermidine-nitrous acid reaction products with uvr- and recA-dependent repair systems in Salmonella.鼠伤寒沙门氏菌中诱变亚精胺-亚硝酸反应产物与uvr和recA依赖性修复系统的相互作用
J Bacteriol. 1980 Apr;142(1):191-5. doi: 10.1128/jb.142.1.191-195.1980.
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Base composition of nonsense codons in E. coli. Evidence from amino-acid substitutions at a tryptophan site in alkaline phosphatase.大肠杆菌中无义密码子的碱基组成。来自碱性磷酸酶色氨酸位点氨基酸取代的证据。
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Repair of DNA in Haemophilus influenzae. II. Excision, repair of single-strand breaks, defects in transformation, and host cell modification in UV-sensitive mutants.流感嗜血杆菌中的DNA修复。II. 紫外线敏感突变体中的切除、单链断裂修复、转化缺陷及宿主细胞修饰
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Identification of the altered bases in mutated single-stranded DNA. IV. Nitrous acid induction of the transitions guanine to adenine and thymine to cytosine.突变单链DNA中碱基改变的鉴定。IV. 亚硝酸诱导鸟嘌呤向腺嘌呤以及胸腺嘧啶向胞嘧啶的转换
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Variation of mutagenic action on nonsense mutants at different sites in the iso-1-cytochrome c gene of yeast.诱变作用对酵母异-1-细胞色素c基因不同位点无义突变体的影响。
Genetics. 1974 Sep;78(1):97-113. doi: 10.1093/genetics/78.1.97.

亚硝酸对双链脱氧核糖核酸的损伤：胞嘧啶残基脱氨基作用与一种新型突变损伤之间的区别。

Nitrous acid damage to duplex deoxyribonucleic acid: distinction between deamination of cytosine residues and a novel mutational lesion.

作者信息

Frankel A D, Duncan B K, Hartman P E

出版信息

J Bacteriol. 1980 Apr;142(1):335-8. doi: 10.1128/jb.142.1.335-338.1980.

DOI:10.1128/jb.142.1.335-338.1980
PMID:6989809
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC293965/
Abstract

The rate of nitrous acid deamination of labeled cytosine residues in native Escherichia coli deoxyribonucleic acid was monitored in vitro by release of acid-soluble counts after treatment with uracil deoxyribonucleic acid glycosylase. The reaction exhibited a lag and was not stimulate by several agents previously shown to enhance base substitution mutagenesis during nitrous acid treatment of duplex deoxyribonucleic acid. We conclude that a significant proportion of nitrous acid induced mutagenic lesions are novel lesions and not cytosine deaminations.

摘要

通过用尿嘧啶脱氧核糖核酸糖基化酶处理后释放的酸溶性计数，在体外监测天然大肠杆菌脱氧核糖核酸中标记的胞嘧啶残基的亚硝酸脱氨基速率。该反应表现出滞后现象，并且不受先前显示在亚硝酸处理双链脱氧核糖核酸期间增强碱基取代诱变的几种试剂的刺激。我们得出结论，亚硝酸诱导的诱变损伤的很大一部分是新的损伤，而不是胞嘧啶脱氨基。