Sole M J, Shum A, VanLoon G R
Cardiovasc Res. 1978 Jun;12(6):573-5.
Serotonin and its major metabolite 5-hydroxyindoleacetic acid were measured in the pons-medulla, midbrain, posterior hypothalamus, anterior hypothalamus, thalamus, and cerebellum of cardiomyopathic hamsters and their age-matched controls during the early and terminal stages of the cardiomyopathy. During the stage of cardiac decompensation, significant increases were observed in the concentration of serotonin in pons-medulla (2.30 +/- 0.07 vs 1.74 +/- 0.04; P less than 0.001) and posterior hypothalamus (3.49 +/- 0.04 vs. 3.04 +/- 0.11; P less than 0.005) and in 5-hydroxyindoleacetic acid in pons-medulla (1.42 +/- 0.05 vs 0.97 +/- 0.05; P less than 0.001) and posterior hypothalamus (1.65 +/- 0.02 vs 1.32 +/- 0.07; P less than 0.001). No changes were noted in any of the brain regions of control animals. We conclude that congestive heart failure may be associated with alterations in activity of bulbohypothalamic serotonergic nerves.
在心肌病仓鼠及其年龄匹配的对照仓鼠的心肌病早期和终末期，检测了脑桥延髓、中脑、下丘脑后部、下丘脑前部、丘脑和小脑的血清素及其主要代谢产物5-羟吲哚乙酸。在心脏失代偿阶段，观察到脑桥延髓（2.30±0.07对1.74±0.04；P<0.001）和下丘脑后部（3.49±0.04对3.04±0.11；P<0.005）的血清素浓度以及脑桥延髓（1.42±0.05对0.97±0.05；P<0.001）和下丘脑后部（1.65±0.02对1.32±0.07；P<0.001）的5-羟吲哚乙酸显著增加。对照动物的任何脑区均未发现变化。我们得出结论，充血性心力衰竭可能与延髓下丘脑血清素能神经活动的改变有关。
