Kersey J H, Kruger J, Song C, Kloster B
Transplantation. 1980 May;29(5):388-91. doi: 10.1097/00007890-198005000-00008.
Current studies were designed to provide long-term survival of allogeneic skin and bone marrow in mice preconditioned with various combinations of cyclophosphamide (CY) and/or total lymphoid irradiation (TLI). Long-term skin graft and bone marrow survival was obtained across the major histocompatibility barrier (BALB/c into C57BL/6) using pregrafting conditioning with either fractionated TLI or the combination of CY with a single dose of TLI. CY alone and a single dose of TLI alone were relatively ineffective as pregrafting immunosuppressive combinations. Allogeneic bone marrow was required for long-term skin graft survival with either conditioning regimen. Allogeneic marrow transplantation resulted in somewhat more deaths than syngeneic transplantation with both CY + TLI and fractionated TLI.
当前的研究旨在通过用环磷酰胺（CY）和/或全身淋巴照射（TLI）的各种组合对小鼠进行预处理，来实现异体皮肤和骨髓的长期存活。使用分次TLI或CY与单次TLI联合进行移植前预处理，跨越主要组织相容性屏障（从BALB/c到C57BL/6）获得了长期的皮肤移植和骨髓存活。单独使用CY和单独使用单次TLI作为移植前免疫抑制组合相对无效。两种预处理方案中，长期皮肤移植存活都需要异体骨髓。与CY + TLI和分次TLI的同基因移植相比，异体骨髓移植导致的死亡略多。
