分子生物学对黏液病毒临床病毒学的最新贡献。
Recent contributions of molecular biology to the clinical virology of myxoviruses.
作者信息
Kilbourne E D
出版信息
Yale J Biol Med. 1980 Jan-Feb;53(1):41-5.
Abstract
Recent advances in the clinical virology of influenza are based on non-pragmatically oriented research on the genetics and biochemistry of the influenza virus. Antigenically hybrid recombinant viruses can be tailored to provide monospecific reagents for serological studies. Basic research on viral structure and the mechanism of viral replication has directly influenced the establishment of a cell culture system suitable for the isolation of most influenza viruses. Identification of viral genotype by RNA gel electrophoresis and mapping of oligonucleotides of viral RNA has already facilitated epidemiologic investigations. The clinical virologist of the future must have an understanding of the potential limitations of these techniques for specific strain identification.
摘要
流感临床病毒学的最新进展基于对流感病毒遗传学和生物化学的非实用性研究。可以定制抗原性杂交重组病毒，以提供用于血清学研究的单特异性试剂。关于病毒结构和病毒复制机制的基础研究直接影响了适合分离大多数流感病毒的细胞培养系统的建立。通过RNA凝胶电泳鉴定病毒基因型以及绘制病毒RNA的寡核苷酸图谱已经促进了流行病学调查。未来的临床病毒学家必须了解这些技术在特定毒株鉴定方面的潜在局限性。
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