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慢性精神分裂症血液透析的临床试验。

Clinical trial of hemodialysis in chronic schizophrenia.

作者信息

Sidorowicz S, Firko M, Wasik A, Szewczyk Z, Szepietowski T, Weyde W

出版信息

Acta Psychiatr Scand. 1980 Mar;61(3):223-7. doi: 10.1111/j.1600-0447.1980.tb00871.x.

DOI:10.1111/j.1600-0447.1980.tb00871.x
PMID:6990693
Abstract

The hemodialysis program was carried out in four male chronic schizophrenic patients hospitalized 3--12 months in the Psychiatric Clinic, Medical University, Wroclaw. The diagnosis was made independently by three psychiatrists. The disease lasted 5 to 26 years. The clinical assessment of mental and physical state followed each dialysis. The BPRS, CGI and Wing's Ward Behavior Scale were filled. Eleven to 20 dialyses were conducted once a week (two patients) or twice weekly (two patients). Neuroleptics were withdrawn. A short period of slight, unspecific improvement was followed by a deterioration in all cases, which made it necessary to put the patients back on neuroleptics. At the end of the dialysis program none of the patients improved. Further research on the efficacy of dialysis in chronic schizophrenia should be made before the final assessment of its value.

摘要

血液透析项目在弗罗茨瓦夫医科大学精神病诊所住院3至12个月的4名男性慢性精神分裂症患者中进行。诊断由三名精神科医生独立做出。病程为5至26年。每次透析后都对精神和身体状况进行临床评估。填写了简明精神病评定量表(BPRS)、临床总体印象量表(CGI)和温氏病房行为量表。11至20次透析,两名患者每周进行一次,另外两名患者每周进行两次。停用了抗精神病药物。所有病例在短期出现轻微、非特异性改善后均出现病情恶化,这使得有必要让患者重新使用抗精神病药物。在透析项目结束时,没有一名患者病情改善。在对透析治疗慢性精神分裂症的价值进行最终评估之前,应进一步研究其疗效。

相似文献

1
Clinical trial of hemodialysis in chronic schizophrenia.慢性精神分裂症血液透析的临床试验。
Acta Psychiatr Scand. 1980 Mar;61(3):223-7. doi: 10.1111/j.1600-0447.1980.tb00871.x.
2
The therapeutic efficacy of hemodialysis in schizophrenia.
N Engl J Med. 1983 Mar 24;308(12):669-75. doi: 10.1056/NEJM198303243081201.
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Schizophrenia, hemodialysis, and the placebo effect. Results and issues.
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Dialysis for schizophrenia: an uncontrolled study of 11 patients.精神分裂症的透析治疗:对11例患者的非对照研究。
Am J Psychiatry. 1981 May;138(5):662-5. doi: 10.1176/ajp.138.5.662.
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[Hemodialysis in patients with chronic schizophrenia (author's transl)].慢性精神分裂症患者的血液透析(作者译)
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Five-year trial of dialytic treatment for schizophrenia.精神分裂症透析治疗的五年试验
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