Resnik R, Brink G W
Am J Obstet Gynecol. 1980 May 15;137(2):267-70. doi: 10.1016/0002-9378(80)90784-x.
Two effects of prostacyclin (PGI2) on uterine blood flow were investigated in nonpregnant, castrated ewes with chronically implanted polyvinyl catheters and electromagnetic flow probes. Intra-arterial infusion of PGI2 resulted immediately in increased uterine blood flow, which returned rapidly to baseline after termination of the infusion. A dose-response curve was constructed and demonstrated that a uterine arterial PGI2 concentration of 1.2 times 10(-6)M (0.5 microgram/ml) produced flows 50% of those achieved by a reference dose of 1 microgram of 17 beta-estradiol. Increases in uterine blood flow were not associated with changes in mean systemic arterial pressure. These findings demonstrate that PGI2 has a vasodilatory effect on the uterine circulation and suggest that this substance has a role in the regulation of uterine blood flow.
在非妊娠、去势且长期植入聚乙烯导管和电磁流量探头的母羊中，研究了前列环素（PGI2）对子宫血流的两种作用。动脉内输注PGI2可立即导致子宫血流增加，输注终止后血流迅速恢复至基线水平。构建了剂量反应曲线，结果表明，子宫动脉PGI2浓度为1.2×10⁻⁶M（0.5微克/毫升）时产生的血流量为1微克17β-雌二醇参考剂量所达到血流量的50%。子宫血流增加与平均体循环动脉压的变化无关。这些发现表明，PGI2对子宫循环具有血管舒张作用，并提示该物质在子宫血流调节中发挥作用。
