Rosenfeld C R, Rivera R
Am J Obstet Gynecol. 1978 Oct 15;132(4):442-8. doi: 10.1016/0002-9378(78)90782-2.
Uterine arterial blood flow dose-response curves to systemic infusions of either estrone (E1) or estradiol-17alpha (E2alpha) were determined in ten oophorectomized, nonpregnant ewes. Maximum uterine blood flow occurred with 5 microgram per kilogram of E1 and greater than or equal to 20 microgram per kilogram of E2alpha. Total uterine blood flow measured with isotope-labeled microspheres rose more than tenfold following 30 microgram per kilogram of either estrogen, as did blood flow to the myometrium, endometrium, and uterine caruncles (p less than 0.05). Distribution of uterine blood flow was unaltered. Cervical and vaginal blood flows increased ten-to twenty-fold with E1 and E2alpha, while mammary gland blood flow rose 54 and 77 per cent. Significant increases in adrenal and thyroid blood flows were documented. The only significant decrease in blood flow occurred in the pancreas (- 13 percent; p less than 0.05) following E2alpha infusion. At the dose studied, E1 and E2alpha are potent vasodilators of reproductive tissues, especially the cervix and vagina. As they appear to be the major estrogens during ovine pregnancy, it is likely they participate in the preparation of these tissues for parturition.
在十只切除卵巢的未孕母羊中，测定了子宫动脉血流对全身输注雌酮（E1）或17α-雌二醇（E2α）的剂量反应曲线。每千克体重5微克的E1以及每千克体重大于或等于20微克的E2α可使子宫血流达到最大值。用同位素标记微球测量的子宫总血流量在每千克体重输注30微克任一种雌激素后增加了十多倍，子宫肌层、子宫内膜和子宫肉阜的血流量也是如此（p<0.05）。子宫血流分布未改变。E1和E2α可使宫颈和阴道血流量增加10到20倍，而乳腺血流量分别增加54%和77%。肾上腺和甲状腺血流量也有显著增加。输注E2α后，唯一血流量显著减少的是胰腺（-13%；p<0.05）。在所研究的剂量下，E1和E2α是生殖组织尤其是宫颈和阴道的强效血管舒张剂。由于它们似乎是绵羊妊娠期间的主要雌激素，它们很可能参与了这些组织为分娩所做的准备。
