Lakova E, Stoĭnev A
Eksp Med Morfol. 1981;20(3):134-9.
Conditions for Simultaneous stimulation of cerebral and renal renin-angiotension systems (RAS) are created in the examined by us model of combined cerebral and renal ischemic hypertension. As a results of interaction between them the effect o cerebral RAS predominates, since renin concentration in the medulla oblongata is elevated while the renal renin concentration remains unchanged, but the plasma renin activity is lowered. The blocking of the action of cerebral angiotension by the venously administered angiotensin antagonist saralasin does not alter substantially blood pressure, but causes elevation of the renal renin concentration in the ischemic and intact kidney and normalization of plasma renin activity, without affecting the level of sodium and potassium.
在我们构建的脑肾联合缺血性高血压模型中，创造了同时刺激脑和肾肾素-血管紧张素系统（RAS）的条件。由于它们之间的相互作用，脑RAS的作用占主导，因为延髓中的肾素浓度升高，而肾肾素浓度保持不变，但血浆肾素活性降低。静脉注射血管紧张素拮抗剂沙拉新阻断脑血管紧张素的作用，对血压没有实质性影响，但会导致缺血和未受损肾脏中肾素浓度升高以及血浆肾素活性恢复正常，且不影响钠和钾的水平。
