Cichocki T, Hanicki Z, Klein A, Komorowska Z, Sarnecka-Keller M, Sułowicz W
Kidney Int. 1980 Feb;17(2):231-6. doi: 10.1038/ki.1980.26.
To investigate further the biologic activity of solutes in the middle-molecular-weight range, we studied the influence of these compounds on the migration of unseparated white blood cells and separated granulocytes and lymphocytes. Middle molecules (MM) inhibit the migration of unseparated leukocytes, but this effect on lymphocytes was seldom observed. With scanning electron microscopy, unseparated leukocytes were shown to adhere to one another, forming cellular clumps. This phenomenon could not be seen when separated cells were used. These results give some insight into the mechanism of inhibition exerted by MM and into the changes, observed in earlier experiments, of cellular composition of skin exudate obtained from untreated patients with uremia.
为了进一步研究中等分子量范围内溶质的生物活性，我们研究了这些化合物对未分离的白细胞以及分离出的粒细胞和淋巴细胞迁移的影响。中等分子（MM）抑制未分离白细胞的迁移，但这种对淋巴细胞的作用很少观察到。通过扫描电子显微镜观察发现，未分离的白细胞彼此黏附，形成细胞团块。使用分离的细胞时则看不到这种现象。这些结果为MM发挥抑制作用的机制以及在早期实验中观察到的未经治疗的尿毒症患者皮肤渗出液细胞组成变化提供了一些见解。
