Szigeti R, Masucci M G, Masucci G, Klein E, Klein G
Nature. 1980 Dec 11;288(5791):594-6. doi: 10.1038/288594a0.
Although first recognized by its effect on virus-cell interactions, interferon (IFN) has a variety of other effects. It can affect cell proliferation, modify the immune response at several levels, enhance the cytotoxic action of lymphocytes, suppress antibody formation and inhibit the development of delayed-type hypersensitivity (DTH) reactions. Therefore we have now tested the effect of interferon on leukocyte migration inhibition (LMI), regarded as the counterpart in vitro of DTH in humans. We have found that IFN suppresses both mitogen-and antigen-induced LMI, acting directly on the granulocytes but also affecting the lymphokine production of the lymphocytes.
虽然干扰素（IFN）最初是因其对病毒-细胞相互作用的影响而被认识，但它还有多种其他作用。它可以影响细胞增殖，在多个层面改变免疫反应，增强淋巴细胞的细胞毒性作用，抑制抗体形成，并抑制迟发型超敏反应（DTH）的发生。因此，我们现在测试了干扰素对白细胞迁移抑制（LMI）的影响，LMI被认为是人类DTH在体外的对应物。我们发现，干扰素既能抑制有丝分裂原诱导的LMI，也能抑制抗原诱导的LMI，它直接作用于粒细胞，但也会影响淋巴细胞的淋巴因子产生。
