大鼠气管支气管分泌物中的纤溶酶：纤溶酶原激活物的存在
Fibrinolytic enzyme in tracheobronchial secretion of rats: existence of plasminogen activator.
作者信息
Kosugi T, Morimitsu T, Matsuo O, Mihara H
出版信息
Laryngoscope. 1980 Jun;90(6 Pt 1):1045-51. doi: 10.1002/lary.1980.90.6.1045.
It is known that a plasminogen activator exists in the secretion of various organs, i.e., the existence of plasminogen activator in milk, tears, saliva, seminal fluids, urine and bile has been already demonstrated. However, the existence of the fibrinolytic enzyme in tracheobronchial secretions has not been known until this time. We found a new method to collect the tracheobronchial secretion of rats, and succeeded in detecting the fibrinolytic activity in the tracheobronchial secretions. Furthermore, it was found that the substance exhibiting the fibrinolytic activity in this secretion was not protease but plasminogen activator. In addition, some chemical properties of this plasminogen activator are presented, and the physiological and pathophysiological significances of it are discussed in this paper.
众所周知，多种器官的分泌物中存在纤溶酶原激活物，即已证实在乳汁、眼泪、唾液、精液、尿液和胆汁中存在纤溶酶原激活物。然而，直到现在，气管支气管分泌物中纤维蛋白溶解酶的存在尚不为人所知。我们发现了一种收集大鼠气管支气管分泌物的新方法，并成功检测到了气管支气管分泌物中的纤维蛋白溶解活性。此外，还发现该分泌物中表现出纤维蛋白溶解活性的物质不是蛋白酶，而是纤溶酶原激活物。此外，本文还介绍了这种纤溶酶原激活物的一些化学性质，并讨论了其生理和病理生理意义。
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