Nantulya V M, Doyle J J, Jenni L
Parasitology. 1980 Feb;80(1):123-31. doi: 10.1017/s0031182000000573.
Cyclical transmission of different variable antigen types of Trypanosoma congolense STIB 228 resulted in the development of metacyclic trypanosome populations which were similar in their variable antigen composition as judged by immunofluorescence and neutralization assays. The variable antigen types present in the ingested bloodstream populations were not found in the metacyclic populations. The bloodstream populations which were obtained from cyclically infected, irradiated (900 rad.) mice contained variable antigen types which were not present in the corresponding metacyclic populations. When derivatives of 2 other stocks of T. congolense, isolated in different area of Tanzania, underwent cyclical development in the tsetse fly, the metacyclic populations of each stock also had a characteristic variable antigen composition. The metacyclic populations of the 3 stocks were, however, completely dissimilar in variable antigen composition. Simultaneous infection of tsetse flies with a mixture of different stocks resulted in the concurrent production of metacyclic trypanosomes which contained the characteristic variable antigen types of each stock. The effect of cyclical transmission on the process of antigenic variation in T. congolense infections is therefore similar to that in T. brucei infections.
刚果锥虫STIB 228不同可变抗原类型的周期性传播导致了循环后期锥虫群体的形成，通过免疫荧光和中和试验判断，这些群体的可变抗原组成相似。摄入的血流群体中存在的可变抗原类型在循环后期群体中未被发现。从经周期性感染、照射（900拉德）的小鼠获得的血流群体含有相应循环后期群体中不存在的可变抗原类型。当在坦桑尼亚不同地区分离的另外2株刚果锥虫株的衍生物在采采蝇中进行周期性发育时，每株的循环后期群体也具有特征性的可变抗原组成。然而，这3株的循环后期群体在可变抗原组成上完全不同。用不同株的混合物同时感染采采蝇导致同时产生含有各株特征性可变抗原类型的循环后期锥虫。因此，周期性传播对刚果锥虫感染中抗原变异过程的影响与布氏锥虫感染中的情况相似。
