D'Alecy L G, Rose C J, Sellers S A, Manfredi J P
Am J Physiol. 1980 Jun;238(6):H868-75. doi: 10.1152/ajpheart.1980.238.6.H868.
The single-pass extraction of sodium was measured with and without sympathetic stimulation in dogs anesthetized with alpha-chloralose. A mixture of the test (24Na) and reference ([125I]RISA) substances was injected as a bolus into the common carotid artery. Single-drop samples were taken at approximately 1-s intervals from the sagittal sinus and the temporal sinus while cerebral blood flow was continuously measured at the temporal sinus by the venous outflow technique. The extraction measurements were used to test for extracerebral contamination of venous outflow. The mean integral extraction determined from sagittal sinus samples was 2.2% during control conditions and 3.0% during sympathetic stimulation. The mean temporal sinus extraction of sodium was 6.9% during control and 2.7% during sympathetic stimulation. If true cerebral sodium extraction is assumed to be 1.4% and extracerebral sodium extraction is 60%, then these data indicate that extracerebral contamination is less than 10%.
在用α-氯醛糖麻醉的狗身上，分别在有无交感神经刺激的情况下测量了钠的单次提取量。将测试物质（24Na）和参考物质（[125I]RISA）的混合物作为团注注入颈总动脉。从矢状窦和颞窦每隔约1秒采集单滴样本，同时通过静脉流出技术在颞窦连续测量脑血流量。提取测量用于检测静脉流出的脑外污染情况。在对照条件下，从矢状窦样本确定的平均积分提取率为2.2%，在交感神经刺激期间为3.0%。钠的平均颞窦提取率在对照时为6.9%，在交感神经刺激时为2.7%。如果假设真实的脑钠提取率为1.4%，脑外钠提取率为60%，那么这些数据表明脑外污染小于10%。
