Molteni A, Nickerson P A, Latta J, Brownie A C
Virchows Arch B Cell Pathol. 1975 Nov 21;19(3):191-203. doi: 10.1007/BF02889368.
Implantation of a mammotropic tumor (MtTF4), secreting growth hormone, prolactin, and corticotropin, in female rats of Fischer F344 strain causes hypertension, vasculitis, renal and cardiac hypertrophy, and extensive renal and cardiac lesions. When rats of the same strain were implanted with the MtTF4 tumor but sodium was withheld from the diet, systolic blood pressure rose more slowly but by six weeks reached the same values recorded in the animals implanted with the tumor and allowed to consume sodium ad libitum. In the rats, on sodium deficient diet, however, the vascular damage as well as the renal and cardiac lesions were minimal or absent. Implantation of the tumor caused adrenal cortical dysfunction, and elevated levels of deoxycorticosterone were seen in the peripheral plasma of the rats of all three groups. Nonetheless, plasma deoxycorticosterone was significantly lower in rats on a sodium deficient diet as compared with those having sodium added to the diet. Light microscopic and ultrastructural studies of the adrenal glands revealed that the lack of dietary sodium largely prevented the extensive damage of the zona fasciculata cells usually seen in the tumor-bearing rats, consuming sodium ad libitum. Both hypertensive MtT tumor-bearing animals and normotensive controls on a sodium deficient diet had a conspicuous increase of renal content of renin. It is evident that hypertension may be produced in rats bearing the MtTF4 tumor even in the virtual absence of dietary sodium. It does not appear that the hypersecretion of renal renin sustains the hypertension in these rats, since high levels of this substance were seen in the kidney of normotensive controls on the same sodium deficient diet. Elevated levels of plasma DOC may possibly explain the hypertension. In addition, it is likely that the animals may also have elevated levels of glucocorticoids.
在Fischer F344品系的雌性大鼠体内植入分泌生长激素、催乳素和促肾上腺皮质激素的促乳腺肿瘤（MtTF4），会导致高血压、血管炎、肾脏和心脏肥大以及广泛的肾脏和心脏病变。当给同一品系的大鼠植入MtTF4肿瘤，但饮食中不添加钠时，收缩压上升得较慢，但到六周时达到了植入肿瘤并随意摄入钠的动物所记录的相同水平。然而，在饮食缺钠的大鼠中，血管损伤以及肾脏和心脏病变很轻微或不存在。植入肿瘤导致肾上腺皮质功能障碍，在所有三组大鼠的外周血浆中都观察到脱氧皮质酮水平升高。尽管如此，与饮食中添加钠的大鼠相比，饮食缺钠的大鼠血浆脱氧皮质酮水平显著降低。对肾上腺的光镜和超微结构研究表明，饮食中缺乏钠在很大程度上防止了通常在随意摄入钠的荷瘤大鼠中所见的束状带细胞的广泛损伤。饮食缺钠的高血压荷MtT肿瘤动物和血压正常的对照组肾脏中的肾素含量都显著增加。很明显，即使在几乎没有饮食钠的情况下，植入MtTF4肿瘤的大鼠也可能产生高血压。在这些大鼠中，肾素分泌过多似乎并不能维持高血压，因为在相同饮食缺钠的血压正常对照组的肾脏中也发现了高水平的这种物质。血浆脱氧皮质酮水平升高可能是高血压的原因。此外，这些动物体内的糖皮质激素水平可能也升高了。
