Chemoneurolysis of the canine gastric submucosa: effects of surgically induced gastric hypersecretion in the Pavlov pouch.

Innervated (Pavlov) gastric fundic pouches were constructed in dogs. One group of dogs served as controls, and another group of dogs had their pouch submucosa infiltrated with 25 per cent ethyl alcohol. The alcohol infiltration of the gastric pouch submucosa eliminated the gastric secretory responses to histamine, pentagastrin, a meat meal, and insulin-induced hypoglycemia. The alcohol infusion of the gastric pouch submucosa did not modify the elevated serum gastrin levels to a meat meal, alter the basal or stimulated mean splenic arterial blood flow to the pouch, nor alter the histologic appearance of the pouch with hematoxylin and eosin or histochemical fluorescence of catecholamines. Transplantation of 75 per cent of the gastric antrum into the colon caused a basal and a meal-augmented hypergastrinemia in all dogs. In the control Pavlov pouches the hypergastrinemia induced elevated gastric secretory responses to histamine, pentagastrin, and insulin-induced hypoglycemia. In those Pavlov pouches in which the submucosa had been infiltrated with alcohol, the hypergastrinemia could not induce any gastric secretory response to histamine, pentagastrin, or insulin-induced hypoglycemia.