Schapiro H, Jackson N J, Chaudhuri T K, Michie D D
Am Surg. 1980 Apr;46(4):252-9.
Innervated (Pavlov) gastric fundic pouches were constructed in dogs. One group of dogs served as controls, and another group of dogs had their pouch submucosa infiltrated with 25 per cent ethyl alcohol. The alcohol infiltration of the gastric pouch submucosa eliminated the gastric secretory responses to histamine, pentagastrin, a meat meal, and insulin-induced hypoglycemia. The alcohol infusion of the gastric pouch submucosa did not modify the elevated serum gastrin levels to a meat meal, alter the basal or stimulated mean splenic arterial blood flow to the pouch, nor alter the histologic appearance of the pouch with hematoxylin and eosin or histochemical fluorescence of catecholamines. Transplantation of 75 per cent of the gastric antrum into the colon caused a basal and a meal-augmented hypergastrinemia in all dogs. In the control Pavlov pouches the hypergastrinemia induced elevated gastric secretory responses to histamine, pentagastrin, and insulin-induced hypoglycemia. In those Pavlov pouches in which the submucosa had been infiltrated with alcohol, the hypergastrinemia could not induce any gastric secretory response to histamine, pentagastrin, or insulin-induced hypoglycemia.
在狗身上构建了有神经支配的（巴甫洛夫）胃底袋。一组狗作为对照，另一组狗的胃袋黏膜下层用25%的乙醇浸润。胃袋黏膜下层的乙醇浸润消除了对组胺、五肽胃泌素、肉餐和胰岛素诱导的低血糖的胃分泌反应。胃袋黏膜下层注入乙醇并未改变对肉餐的血清胃泌素水平升高，未改变胃袋的基础或刺激后的平均脾动脉血流量，也未改变胃袋用苏木精和伊红染色后的组织学外观或儿茶酚胺的组织化学荧光。将75%的胃窦移植到结肠中导致所有狗出现基础和进食增强的高胃泌素血症。在对照的巴甫洛夫胃袋中，高胃泌素血症导致对组胺、五肽胃泌素和胰岛素诱导的低血糖的胃分泌反应升高。在黏膜下层已用乙醇浸润的那些巴甫洛夫胃袋中，高胃泌素血症不能诱导对组胺、五肽胃泌素或胰岛素诱导的低血糖的任何胃分泌反应。
