Keuppens F, Bremen J, Woussen-Colle M C, De Graef J
Surgery. 1976 Nov;80(5):586-90.
In four dogs with Heidenhain pouche, acid outputs from the pouch were measured in response to feeding boiled liver with or without simultaneous administration of pentagastrin. Antrectomy was performed and the experiments were repeated. Antrectomy decreased the acid response to feeding by 90 percent. The preantrectomy response was restored by infusing pentagastrin but near maximal doses were needed and the maximal response to feeding plus pentagastrin could not be restored. These results indicate that the decrease of the acid secretory response to feeding from Heidenhain pouches after antrectomy cannot be explained fully through suppression of endogenous gastrin release. Antrectomy probably interferes with the intestinal phase of gastric secretion.
在4只具有海登海因小胃的狗中，测量小胃对喂食煮熟肝脏的酸分泌量，同时或不同时给予五肽胃泌素。进行了胃窦切除术并重复实验。胃窦切除术使喂食引起的酸反应降低了90%。通过输注五肽胃泌素可恢复胃窦切除术前的反应，但需要接近最大剂量，且喂食加五肽胃泌素的最大反应无法恢复。这些结果表明，胃窦切除术后海登海因小胃对喂食的酸分泌反应降低不能完全通过内源性胃泌素释放的抑制来解释。胃窦切除术可能干扰了胃分泌的肠期。
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