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各种前体物质对心脏组织中高能磷酸盐和吡啶核苷酸浓度的影响及其对缺氧存活的可能意义。

The influence of various precursors on the concentration of energy-rich phosphates and pyridine nucleotides in cardiac tissue and its possible meaning for anoxic survival.

作者信息

Seifart H I, Delabar U, Siess M

出版信息

Basic Res Cardiol. 1980 Jan-Feb;75(1):57-61. doi: 10.1007/BF02001394.

DOI:10.1007/BF02001394
PMID:6446299
Abstract

A special "anoxia test" was developed with isolated guinea pig atria to test influences on the anoxic energy balance. Adenine, ribose, nicotinic acid or nicotinamide added as precursors to nutrition solutions inhibit the loss of cardiac adenine and pyridine nucleotides during anoxia and improve the energy balance under aerobic and anaerobic conditions in the myocardium.

摘要

利用离体豚鼠心房开发了一种特殊的“缺氧试验”，以测试对缺氧能量平衡的影响。作为营养溶液前体添加的腺嘌呤、核糖、烟酸或烟酰胺可抑制缺氧期间心脏腺嘌呤和吡啶核苷酸的损失，并改善心肌在有氧和无氧条件下的能量平衡。

相似文献

1
The influence of various precursors on the concentration of energy-rich phosphates and pyridine nucleotides in cardiac tissue and its possible meaning for anoxic survival.各种前体物质对心脏组织中高能磷酸盐和吡啶核苷酸浓度的影响及其对缺氧存活的可能意义。
Basic Res Cardiol. 1980 Jan-Feb;75(1):57-61. doi: 10.1007/BF02001394.
2
Cardiac synthesis and degradation of pyridine nucleotides and the level of energy-rich phosphates influenced by various precursors.心脏中吡啶核苷酸的合成与降解以及各种前体对富含能量的磷酸盐水平的影响。
Adv Myocardiol. 1983;4:287-308. doi: 10.1007/978-1-4757-4441-5_26.
3
Anoxic energy production and contractile activity in mammalian cardiac muscle.哺乳动物心肌中的无氧能量产生与收缩活动。
Adv Myocardiol. 1980;2:295-310.
4
Synthesis and degradation of NAD in guinea pig cardiac muscle: I. Dependence upon the extracellular concentration of nicotinamide and nicotinic acid.豚鼠心肌中烟酰胺腺嘌呤二核苷酸（NAD）的合成与降解：I. 对细胞外烟酰胺和烟酸浓度的依赖性。
Basic Res Cardiol. 1979 Sep-Oct;74(5):528-44. doi: 10.1007/BF01907646.
5
Some aspects on the regulation of carbohydrate and lipid metabolism in cardiac tissue.心脏组织中碳水化合物和脂质代谢调节的某些方面。
Basic Res Cardiol. 1980 Jan-Feb;75(1):47-56. doi: 10.1007/BF02001393.
6
In vivo 31P-NMR studies of myocardial high energy phosphate metabolism during anoxia and recovery.缺氧和恢复过程中心肌高能磷酸代谢的体内31P-NMR研究
FEBS Lett. 1983 Aug 8;159(1-2):207-10. doi: 10.1016/0014-5793(83)80447-5.
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[Research on metabolism in acute hypoxia. II. Stationary concentration of adenosine-phosphate and anorganic phosphate in the liver and myocardium of guinea pigs during short hypoxia].[急性缺氧时的代谢研究。II. 短时间缺氧期间豚鼠肝脏和心肌中腺苷磷酸和无机磷酸的稳态浓度]
Beitr Pathol Anat. 1957;118(1):52-66.
8
The effect of hypoxia on cardiac tissue. I. High energy phosphates content and oxygen uptake.缺氧对心脏组织的影响。I. 高能磷酸盐含量与氧摄取
Eur J Pharmacol. 1969 Oct;8(1):19-24. doi: 10.1016/0014-2999(69)90124-1.
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[Energy-rich phosphate of the myocardium in variation of the loading conditions. Experiments on heart-lung preparation in the guinea pig].[负荷条件变化时心肌的高能磷酸酯。豚鼠心肺制备实验]
Pflugers Arch Gesamte Physiol Menschen Tiere. 1960;271:548-63.
10
Atrial bioenergetic variations in moderate hypoxia: danger or protective defense?中度缺氧时心房生物能量的变化：危险还是保护性防御？
Basic Res Cardiol. 1989 Sep-Oct;84(5):449-60. doi: 10.1007/BF01908197.

引用本文的文献

1
Regulation of and intervention into the oxidative pentose phosphate pathway and adenine nucleotide metabolism in the heart.心脏中磷酸戊糖氧化途径和腺嘌呤核苷酸代谢的调控与干预。
Mol Cell Biochem. 1996 Jul-Aug;160-161:101-9. doi: 10.1007/BF00240038.
2
Some aspects on the regulation of carbohydrate and lipid metabolism in cardiac tissue.心脏组织中碳水化合物和脂质代谢调节的某些方面。
Basic Res Cardiol. 1980 Jan-Feb;75(1):47-56. doi: 10.1007/BF02001393.
3
Metabolic intervention to affect myocardial recovery following ischemia.影响缺血后心肌恢复的代谢干预。

本文引用的文献

1
Synthesis and degradation of NAD in guinea pig cardiac muscle: I. Dependence upon the extracellular concentration of nicotinamide and nicotinic acid.豚鼠心肌中烟酰胺腺嘌呤二核苷酸（NAD）的合成与降解：I. 对细胞外烟酰胺和烟酸浓度的依赖性。
Basic Res Cardiol. 1979 Sep-Oct;74(5):528-44. doi: 10.1007/BF01907646.
Ann Surg. 1984 Jul;200(1):1-12. doi: 10.1097/00000658-198407000-00001.
4
The oxidative pentose phosphate pathway in the heart: regulation, physiological significance, and clinical implications.心脏中的氧化戊糖磷酸途径：调节、生理意义及临床意义
Basic Res Cardiol. 1992 Jul-Aug;87(4):303-16. doi: 10.1007/BF00796517.