[Macrophage migration inhibition test in mice with experimental amyloidosis].

The migration inhibition factor (MIF) has been detected in sera of both amyloid patients and mice with casein-induced amyloidosis. This factor inhibits the migration of intact mouse splenocytes and peritoneal macrophages of the guinea pig. The same activity is also displayed by sera of guinea pig. The same activity is also displayed by sera of patients with chronic active hepatitis, liver cirrhosis and systemic lupus erythematosus. Spontaneous migration of splenocytes was studied in the course of casein-induced amyloidosis in mice. In the early stages of antigenic stimulation there was an increase in the cell migration activity, corresponding with the morphological picture of pyroninophilic and plasma cell proliferation. In the course of further antigenic stimulation the migration activity gradually decreases as the lymphoid tissue gets replaced by amyloid mass. MIF production during amyloidosis is discussed.