Hansen H H, Dombernowsky P, Hirsch F R, Hansen M, Rygård J
Cancer. 1980 Jul 15;46(2):279-84. doi: 10.1002/1097-0142(19800715)46:2<279::aid-cncr2820460210>3.0.co;2-w.
A total of 114 patients with bronchogenic small cell anaplastic carcinoma and staged as having regional disease all underwent combination chemotherapy consisting of CCNU, cyclophosphamide, and methotrexate. They were randomized to receive either radiotherapy to the primary tumor and regional lymph nodes (4000 rad) or extensive radiotherapy, which included the brain, adrenals, and upper retroperitoneal lymph nodes. Fifteen patients were free of disease after 18 months of chemotherapy and the treatment was discontinued. Only 3 patients subsequently relapsed. No difference was observed between the two groups of patients in median survival time, response rate, duration of response or relapse pattern, including the frequency of brain metastasis.
共有114例支气管源性小细胞间变性癌且分期为局部病变的患者均接受了由洛莫司汀、环磷酰胺和甲氨蝶呤组成的联合化疗。他们被随机分为两组，一组接受针对原发肿瘤和区域淋巴结的放疗（4000拉德），另一组接受扩大放疗，包括脑部、肾上腺和上腹膜后淋巴结。15例患者在化疗18个月后疾病缓解，治疗停止。随后只有3例患者复发。两组患者在中位生存时间、缓解率、缓解持续时间或复发模式（包括脑转移频率）方面均未观察到差异。
