Neidhardt J, Schwille P O, Engelhardt W, Gebhardt C, Scholz D, Gall F P
Chir Forum Exp Klin Forsch. 1980:173-7.
Microsurgery, intraductal pancreatic occlusion by an Ethibloc bolus and intravenous glucose load in the rat enable investigations to be made into the feed-back relationships between occlusion-induced acinar atrophy and the response of the islet hormones insulin, glucagon, somatostatin, and glucose tolerance. Thirteen days after duct occlusion the latter is moderately delayed from 40-60 min, serum insulin is lowered, plasma somatostatin unchanged, and plasma glucagon moderately elevated, as compared with sham-operated control animals. It is suggested that the employed experimental conditions reveal an exo-endocrine pancreatic functional axis, but that the results obtained are not representative for states with an intact entero-insular axis.
在大鼠中，显微手术、用Ethibloc团块进行胰腺导管内闭塞以及静脉注射葡萄糖负荷，能够对闭塞诱导的腺泡萎缩与胰岛激素胰岛素、胰高血糖素、生长抑素的反应以及葡萄糖耐量之间的反馈关系进行研究。与假手术对照动物相比，导管闭塞13天后，葡萄糖耐量从40 - 60分钟开始出现中度延迟，血清胰岛素降低，血浆生长抑素无变化，血浆胰高血糖素中度升高。研究表明，所采用的实验条件揭示了一种外分泌-内分泌胰腺功能轴，但所获得的结果并不代表肠-胰岛轴完整的状态。
