Catala J, Bonnafous R, Hollande E
Diabete Metab. 1986 Aug;12(4):203-11.
The effects of pancreatic duct ligation on endocrine function in the rabbit were studied over the short and medium term period (5 to 180 days). Hyperglycaemia appeared 30 days after ligation and persisted until the end of the experimental period (180 days). The highest glucose values were observed on day 90 after ligation (351 +/- 25 mg/100 ml). Glucose loading tests performed 5, 15, 30 and 180 days after ligation showed weak insulin release. Reduced pancreatic insulin stores could not account for this failure. Immunocytochemical studies showed dissociation of the islets (30 days after ligation) leading to small clusters of B cells scattered in a degenerative exocrine tissue (180 days).
研究了兔胰腺导管结扎在短期和中期（5至180天）对内分泌功能的影响。结扎后30天出现高血糖，并持续至实验期结束（180天）。结扎后第90天观察到最高血糖值（351 +/- 25毫克/100毫升）。结扎后5、15、30和180天进行的葡萄糖负荷试验显示胰岛素释放较弱。胰腺胰岛素储备减少不能解释这种失败。免疫细胞化学研究显示胰岛解离（结扎后30天），导致B细胞小簇散布在退化的外分泌组织中（180天）。
