Miyake A, Kurachi H, Kawamura Y, Aono T, Kurachi K, Yanagida T
Endocrinol Jpn. 1980 Feb;27(1):117-9. doi: 10.1507/endocrj1954.27.117.
The concentration of luteinizing hormone-releasing hormone (LH-RH) in both cerebrospinal fluid (CSF) and plasma in 36 women with various conditions were determined, and the correlation of LH-RH concentrations between plasma and CSF was studied. Paired samples of plasma and CSF were obtained just before operation and were extracted with methanol for LH-RH radioimmunoassay. LH and FSH were also measured by radioimmunoassay. The mean plasma LH-RH levels were 3.79 pg/ml in the follicular phase, 4.15 pg/ml in the luteal phase, 12.73 pg/ml in postmenopausal women and 2.31 pg/ml in pregnant women at term. No immunoreactive LH-RH in the CSF was found in 29 out of 36 subjects, and the remaining 7 subjects showed very low levels (less than 0.95 pg/ml). The LH-RH levels in the CSF of post-menopausal women were not higher their those in the remaining 3 groups, although their plasma levels of LH-RH were significantly (p less than 0.001) elevated. The mean plasma levels of LH and FSH in post-menopausal women were significantly higher than those in normal cyclic women and in pregnant women. The present results suggest that little or no LH-RH is present in the CSF, and it is not clear that there is any correlation between the LH-RH level of plasma and those of CSF.
测定了36名患有各种病症的女性脑脊液（CSF）和血浆中促黄体生成激素释放激素（LH-RH）的浓度，并研究了血浆和脑脊液中LH-RH浓度之间的相关性。在手术前采集配对的血浆和脑脊液样本，并用甲醇提取用于LH-RH放射免疫测定。LH和FSH也通过放射免疫测定法测量。卵泡期血浆LH-RH平均水平为3.79 pg/ml，黄体期为4.15 pg/ml，绝经后女性为12.73 pg/ml，足月孕妇为2.31 pg/ml。36名受试者中有29名脑脊液中未发现免疫反应性LH-RH，其余7名受试者水平极低（低于0.95 pg/ml）。绝经后女性脑脊液中的LH-RH水平并不高于其他3组，尽管其血浆LH-RH水平显著升高（p<0.001）。绝经后女性血浆LH和FSH的平均水平显著高于正常周期女性和孕妇。目前的结果表明，脑脊液中存在很少或不存在LH-RH，血浆和脑脊液中LH-RH水平之间是否存在任何相关性尚不清楚。
