杜兴氏肌营养不良症患者红细胞膜的蛋白激酶和腺苷酸环化酶

Protein kinase and adenylate cyclase of erythrocyte membrane from patients with Duchenne muscular dystrophy.

作者信息

Fischer S, Tortolero M, Piau J P, Delaunay J, Schapira G

出版信息

Clin Chim Acta. 1978 Sep 15;88(3):437-40. doi: 10.1016/0009-8981(78)90278-4.

Abstract

In freshly prepared erythrocyte membranes from normal individuals and from patients with Duchenne progressive muscular dystrophy the endogenous protein kinase and the cAMP stimulated phosphorylation was identical for the three main 32P proteins including spectrin (protein band II). Another enzyme, adenylate cyclase, was found unchanged. Altered protein kinase and adenylate cyclase has been reported in this disorder. We have no explanation for these discrepancies.

摘要

在从正常个体以及杜兴氏进行性肌营养不良患者新鲜制备的红细胞膜中，内源性蛋白激酶以及环磷酸腺苷（cAMP）刺激的磷酸化作用，对于包括血影蛋白（蛋白条带II）在内的三种主要的32P蛋白而言是相同的。另一种酶，即腺苷酸环化酶，未发现有变化。据报道，在这种疾病中蛋白激酶和腺苷酸环化酶发生了改变。我们无法解释这些差异。