测量红细胞膜弹性作为杜氏肌营养不良症的辅助诊断方法。
Measurement of erythrocyte membrane elasticity as a diagnostic aid in Duchenne muscular dystrophy.
作者信息
Nash G B, Wyard S J
出版信息
J Med Genet. 1982 Aug;19(4):262-5. doi: 10.1136/jmg.19.4.262.
Abstract
Using a micropipette aspiration technique, erythrocyte membrane shear elastic modulus was determined for 23 patients with Duchenne muscular dystrophy, for 14 female carriers, and for three control groups (age matched boys and adult males and females). On average the elastic modulus was slightly greater than normal for both affected males and female carriers. However, there was overlap in the values from all groups. The decreased deformability of dystrophic membranes demonstrated by the test is not great enough to be used for carrier detection nor to make the possibility of prenatal diagnosis likely.
摘要
采用微量移液器抽吸技术，测定了23例杜氏肌营养不良症患者、14例女性携带者以及三个对照组（年龄匹配的男孩和成年男性与女性）的红细胞膜剪切弹性模量。平均而言，患病男性和女性携带者的弹性模量均略高于正常水平。然而，所有组的值存在重叠。该测试所显示的营养不良膜变形性降低的程度还不足以用于携带者检测，也不太可能实现产前诊断。
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