Watson R D, Stallard T J, Flinn R M, Littler W A
Hypertension. 1980 May-Jun;2(3):333-41. doi: 10.1161/01.hyp.2.3.333.
Intra-arterial pressure was recorded continuously in 26 patients with uncomplicated essential hypertension under standardized conditions. Recordings were analyzed beat by beat to obtain mean pressures and variability, expressed as the standard deviation of the frequency histogram. The major factors influencing variability were the level of pressure and the intensity of physical activity; systolic variability increased with progressive impairment of sino-aortic baroreflexes. Diastolic pressure increased with the level of sympathetic activity as reflected by plasma norepinephrine levels. After allowance for the decrease of plasma renin activity (PRA) with age, direct relationships were observed between PRA (log values) and the level of pressure and systolic variability; plasma angiotensin II values did not correlate. Systolic variability increased with the systolic response to cold but was unrelated to the response to dynamic or isometric exercise. Variability also tended to increase with obesity and was unrelated to age, sex, or race.
在标准化条件下，对26例无并发症的原发性高血压患者连续记录动脉内压力。逐搏分析记录结果以获得平均压力和变异性，用频率直方图的标准差表示。影响变异性的主要因素是压力水平和体力活动强度；随着窦主动脉压力反射进行性损害，收缩压变异性增加。舒张压随交感神经活动水平升高而升高，血浆去甲肾上腺素水平可反映这一点。在考虑到血浆肾素活性（PRA）随年龄下降的因素后，观察到PRA（对数值）与压力水平和收缩压变异性之间存在直接关系；血浆血管紧张素II值无相关性。收缩压变异性随对冷刺激的收缩反应增加而增加，但与对动态或等长运动的反应无关。变异性也往往随肥胖增加而增加，与年龄、性别或种族无关。
