Clinica Medica, Ospedale San Gerardo dei Tintori Monza, University of Milano-Bicocca, Milan, Italy.
Curr Hypertens Rep. 2012 Aug;14(4):333-8. doi: 10.1007/s11906-012-0273-8.
In hypertensive patients the risk of developing cardiovascular events and complications depends not only on the magnitude of the blood pressure elevation, but also, and to a consistent extent, on the presence of associated cardiovascular risk factors, concomitant disease and target organ damage. Recent findings suggest that also sympathetic overdrive and alterations in blood pressure variability (which are detected in hypertension) may participate at the increased cardiovascular risk of the patients with high blood pressure. This review will discuss the evidence collected over the past few years on the relationships between sympathetic activation and blood pressure variability and their impact on cardiovascular risk profile.
在高血压患者中，发生心血管事件和并发症的风险不仅取决于血压升高的幅度，而且还与相关心血管危险因素、并存疾病和靶器官损伤的存在程度一致。最近的研究结果表明，交感神经兴奋过度和血压变异性改变（在高血压中检测到）也可能参与高血压患者心血管风险的增加。这篇综述将讨论过去几年收集的关于交感神经激活和血压变异性之间的关系及其对心血管风险特征的影响的证据。
