de Vries-Hospers H G, van der Waaij D
Infection. 1980;8(2):63-5. doi: 10.1007/BF01639148.
Amphotericin B concentrations were measured in the saliva of ten healthy volunteers who had sucked on lozenges with this drug. It appeared that high amphotericin B concentrations can be achieved in this way in the saliva. Even half an hour after swallowing the last remnant of a lozenge, the amphotericin B concentration was found to be high enough to suppress the growth of sensitive Candida albicans strains. The possible usefulness of amphotericin B lozenges in the selective decontamination of the oropharynx of yeasts and other fungi is discussed and compared with the application of this drug in orabase.
在十名健康志愿者吸吮含两性霉素B含片后的唾液中测量了两性霉素B的浓度。结果显示，通过这种方式可在唾液中达到较高的两性霉素B浓度。即使在咽下含片的最后残余部分半小时后，仍发现两性霉素B浓度足以抑制敏感白色念珠菌菌株的生长。本文讨论了两性霉素B含片在口咽部酵母菌和其他真菌选择性去污中的潜在用途，并与该药物在糊剂中的应用进行了比较。
