de Vries-Hospers H G, van der Waaij D
Infection. 1978;6(1):16-20. doi: 10.1007/BF01641085.
2% amphotericin B in orabase was applied to the buccal mucous membranes of healthy volunteers. Amounts of 1 g and 0.5 g were used. The experiments were performed during the day time as well as during the sleeping hours at night. At several intervals after application saliva samples were collected and the amphotericin B concentrations were determined. Application of 1 g of orabase with 2% amphotericin B appears to maintain a sufficiently high concentration for four hours, 0.5 g for three hours. Application of these amounts before going to sleep guarantees a sufficient concentration until awakening the next morning.
将含2%两性霉素B的羟丙基纤维素凝胶应用于健康志愿者的颊粘膜。使用量分别为1克和0.5克。实验在白天以及夜间睡眠时间进行。给药后在几个时间间隔采集唾液样本并测定两性霉素B的浓度。应用含2%两性霉素B的1克羟丙基纤维素凝胶似乎能在4小时内维持足够高的浓度，0.5克则能维持3小时。睡前使用这些剂量可保证到第二天早晨醒来时都有足够的浓度。
