Sakaguchi T, Yamaguchi K
J Endocrinol. 1980 Apr;85(1):131-6. doi: 10.1677/joe.0.0850131.
To evaluate the physiological role of the vagus nerve in the secretion of insulin in the rat, changes in plasma levels of insulin and sugar were examined after vagotomy with and without adrenalectomy. Male rats, fasted for 22 h, weighing about 300 g and anaesthetized with pentobarbitone sodium were used. Thirty minutes after unilateral or bilateral adrenalectomy, the first blood sample was taken just before pancreatic vagotomy and a second sample was taken 15 min after vagotomy. Pancreatic vagotomy significantly decreased levels of plasma insulin in bilaterally adrenalectomized rats. It was also confirmed that electrical stimulation of the pancreatic vagus nerve provoked an increase in levels of insulin associated with a reduction of carbohydrates in the blood. These observations support the theory that there is a vagal mechanism which modulates the secretion of insulin and suggest that the vagal mechanism is a potent factor although such a mechanism may be masked by the activity of the adrenal gland.
为评估迷走神经在大鼠胰岛素分泌中的生理作用，在有或无肾上腺切除术的情况下，切断迷走神经后检测了胰岛素和血糖的血浆水平变化。选用禁食22小时、体重约300克、用戊巴比妥钠麻醉的雄性大鼠。单侧或双侧肾上腺切除术后30分钟，在胰腺迷走神经切断术前采集第一份血样，迷走神经切断术后15分钟采集第二份血样。胰腺迷走神经切断术显著降低了双侧肾上腺切除大鼠的血浆胰岛素水平。还证实，电刺激胰腺迷走神经可使胰岛素水平升高，同时血液中的碳水化合物减少。这些观察结果支持这样一种理论，即存在一种调节胰岛素分泌的迷走神经机制，并且表明尽管这种机制可能被肾上腺的活动所掩盖，但迷走神经机制是一个重要因素。
