Yamazaki M, Sakaguchi T
Department of Internal Medicine, Niigata University School of Medicine, Japan.
Brain Res. 1989 Apr 10;484(1-2):357-60. doi: 10.1016/0006-8993(89)90381-8.
The vagus glucose signal pathway relevant to hepatic portal control of insulin secretion was examined in bilaterally adrenalectomized rats. The increase in the insulin concentration after portal glucose injection was completely blocked by vagotomy of the hepatic branch which is bifurcated from the ventral vagus trunk at the subdiaphragmatic level. At the cervical level, the reduction in the insulin concentration showed no laterality following vagotomy on either side. The insulin response was mainly suppressed by prior section of the branch of the ventral vagus trunk at the celiac level. These results suggest that the hepatic glucose signal evoking insulin release has a specific pathway from the liver to the pancreas, and that there is functional laterality in this pathway in the visceral cavity.
在双侧肾上腺切除的大鼠中，研究了与肝门对胰岛素分泌的控制相关的迷走神经葡萄糖信号通路。在膈下水平从腹侧迷走神经干分叉的肝支进行迷走神经切断后，门静脉注射葡萄糖后胰岛素浓度的升高被完全阻断。在颈部水平，迷走神经切断后，无论切断哪一侧，胰岛素浓度的降低均无侧别差异。胰岛素反应主要在腹腔干水平腹侧迷走神经干分支预先切断后受到抑制。这些结果表明，引发胰岛素释放的肝葡萄糖信号具有从肝脏到胰腺的特定途径，并且在内脏腔中该途径存在功能上的侧别差异。
