Rubin R H, Fang L S, Jones S R, Munford R S, Slepack J M, Varga P A, Onheiber L, Hall C L, Tolkoff-Rubin N E
JAMA. 1980 Aug 8;244(6):561-64.
Urine specimens from 134 women with acute, uncomplicated urinary tract infection at three medical centers were examined by the antibody-coated bacteria (ACB) assay. Patients with negative assays (suggesting bladder infection alone) were randomized to receive either a single 3-g oral dose of amoxicillin trihydrate or conventional ten-day courses of sulfa-methoxazole-trimethoprim or oral ampicillin sodium. Comparable results were obtained with the three regimens for ACG-negative infection: 90% eradication of the original organism with single-dose amoxicillin, 100% with sulfamethoxazole-trimethoprim, and 96% with ampicillin. The overall incidence of ACB positivity was 32.1%, ranging from 8% to 63% at the three institutions. This difference seemed to be related to the ease of access to medical care: women with easy access having low rates of ACB positivity and those with poor access having high rates.
来自三个医疗中心的134名患有急性单纯性尿路感染的女性的尿液样本，通过抗体包被细菌（ACB）检测法进行了检查。检测结果为阴性的患者（提示仅膀胱感染）被随机分为两组，一组接受单次口服3克三水合阿莫西林，另一组接受传统的为期十天的磺胺甲恶唑-甲氧苄啶或口服氨苄西林钠治疗。对于ACG阴性感染，三种治疗方案的效果相当：单剂量阿莫西林使原感染菌的清除率为90%，磺胺甲恶唑-甲氧苄啶为100%，氨苄西林为96%。ACB阳性的总体发生率为32.1%，在三个机构中从8%到63%不等。这种差异似乎与获得医疗服务的难易程度有关：获得医疗服务容易的女性ACB阳性率较低，而获得医疗服务困难的女性ACB阳性率较高。
