单剂量头孢尼西治疗尿路感染
Single-dose cefonicid therapy for urinary tract infections.
作者信息
Pontzer R E, Krieger R E, Boscia J A, McNamee W, Levison M E, Kaye D
出版信息
Antimicrob Agents Chemother. 1983 Jun;23(6):814-6. doi: 10.1128/AAC.23.6.814.
The efficacy of single-dose therapy with cefonicid (1 g intramuscularly) and multidose therapy with amoxicillin (500 mg orally three times a day for 7 days) was compared for the treatment of uncomplicated lower urinary tract infection in women. Of 50 patients with symptoms of lower urinary tract infection randomized to receive either cefonicid or amoxicillin, 39 were infected with greater than or equal to 10(5) bacteria per ml. At early posttherapy follow-up (5 to 18 days), 19 of 21 (90%) cefonicid-treated patients and 16 of 18 (89%) amoxicillin-treated patients were cured. At late posttherapy follow-up (6 to 7 weeks), 16 of 18 (89%) cefonicid-treated patients and 14 of 15 (93%) amoxicillin-treated patients were cured. One patient was lost to follow-up in each late follow-up group. There were fewer side effects in the cefonicid-treated group. There were significantly more organisms resistant to amoxicillin than to cefonicid in the study population. Considering the small size of the series, single-dose therapy with cefonicid for lower urinary tract infection in women appears to be as safe and effective as conventional multidose therapy with amoxicillin.
比较了头孢尼西单剂量疗法（1克肌肉注射）和阿莫西林多剂量疗法（500毫克口服，每日三次，共7天）治疗女性单纯性下尿路感染的疗效。在50例有下尿路感染症状且随机接受头孢尼西或阿莫西林治疗的患者中，39例每毫升感染菌数大于或等于10⁵ 。在治疗后早期随访（5至18天）时，21例接受头孢尼西治疗的患者中有19例（90%）治愈，18例接受阿莫西林治疗的患者中有16例（89%）治愈。在治疗后晚期随访（6至7周）时，18例接受头孢尼西治疗的患者中有16例（89%）治愈，15例接受阿莫西林治疗的患者中有14例（93%）治愈。每个晚期随访组各有1例患者失访。头孢尼西治疗组的副作用较少。在研究人群中，对阿莫西林耐药的微生物明显多于对头孢尼西耐药的微生物。鉴于该系列研究规模较小，头孢尼西单剂量疗法治疗女性下尿路感染似乎与阿莫西林传统多剂量疗法一样安全有效。
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