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核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

Lee S P, Clarke A C, Tasman-Jones C

Clin Exp Pharmacol Physiol. 1978 Jul-Aug;5(4):383-5. doi: 10.1111/j.1440-1681.1978.tb00687.x.

Rats after a 24 h restraint developed acute gastric erosions. Cimetidine in a dose of 100 mg/kg body weight was given subcutaneously every 8 h to a group of 150 rats after restraint. A second group received saline subcutaneously (placebo group). 2. Erosions in the placebo group required up to 45 days to heal (median healing time approximately 24 days). Cimetidine treatment reduced the median healing time to approximately 12 days. 3. Cimetidine in this dose promotes healing of acute gastric erosions in the rat induced by restraint.

经过24小时束缚的大鼠出现了急性胃糜烂。对一组150只束缚后的大鼠，每8小时皮下注射100毫克/千克体重的西咪替丁。第二组皮下注射生理盐水（安慰剂组）。2. 安慰剂组的糜烂需要长达45天才能愈合（中位愈合时间约为24天）。西咪替丁治疗将中位愈合时间缩短至约12天。3. 此剂量的西咪替丁可促进束缚诱导的大鼠急性胃糜烂的愈合。

Lee S P, Clarke A C, Tasman-Jones C

Clin Exp Pharmacol Physiol. 1978 Jul-Aug;5(4):383-5. doi: 10.1111/j.1440-1681.1978.tb00687.x.

Rats after a 24 h restraint developed acute gastric erosions. Cimetidine in a dose of 100 mg/kg body weight was given subcutaneously every 8 h to a group of 150 rats after restraint. A second group received saline subcutaneously (placebo group). 2. Erosions in the placebo group required up to 45 days to heal (median healing time approximately 24 days). Cimetidine treatment reduced the median healing time to approximately 12 days. 3. Cimetidine in this dose promotes healing of acute gastric erosions in the rat induced by restraint.

经过24小时束缚的大鼠出现了急性胃糜烂。对一组150只束缚后的大鼠，每8小时皮下注射100毫克/千克体重的西咪替丁。第二组皮下注射生理盐水（安慰剂组）。2. 安慰剂组的糜烂需要长达45天才能愈合（中位愈合时间约为24天）。西咪替丁治疗将中位愈合时间缩短至约12天。3. 此剂量的西咪替丁可促进束缚诱导的大鼠急性胃糜烂的愈合。