Lisak R P
Neurology. 1980 Jul;30(7 Pt 2):99-105. doi: 10.1212/wnl.30.7_part_2.99.
I have attempted to review the evidence that one or more immunopathologic mechanisms are responsible for the clinical and pathologic findings in multiple sclerosis (MS). I believe that there is considerable evidence for an immunopathogenesis of MS, but it is not clear what type or types of reactions are involved or against which autoantigen, neoantigen, or microbial antigen the reaction is directed. In addition, there is growing evidence that there are abnormalities in immunologic control mechanisms in patients with MS, although whether these changes are a cause or a result of the disease is not clear.
我已尝试回顾相关证据，这些证据表明一种或多种免疫病理机制与多发性硬化症（MS）的临床和病理表现有关。我认为有大量证据支持MS的免疫发病机制，但尚不清楚涉及何种类型的反应，也不清楚该反应针对的是何种自身抗原、新抗原或微生物抗原。此外，越来越多的证据表明MS患者的免疫控制机制存在异常，尽管这些变化是疾病的原因还是结果尚不清楚。
