Wyklicky H
Wien Klin Wochenschr. 1980 Feb 29;92(5):165-71.
Even before the turn of the century, the dermatologist Leopold Freund tried to treat a hairy naevus on the back of a child with the rays Roentgen had discovered in 1895 when all known forms of therapy had failed. Loss of hair, as desired, resulted therein. In order to prove that electric currents were not the effective agent, Freund abducted them and treated another part of the naevus pigmentosus piliferus, however, for a longer period in order to compensate for the supposed loss of energy. An ulcer resulted. A number of renowned researchers doubted the biological effect of the X-rays. Freund also began to doubt his original opinion and later even attacked his very own discovery. Only the findings of Robert Kienböck, after having carefully examined them, let Freund accept his former opinion again. Guido Holzknecht, recognized as a pioneer of X-ray diagnosis even before the First World War, occupied himself successfully with X-ray therapy under the influence of Kienböck. He may be regarded as one of the world's first radiobiologists. Vincenz Czerny, of Austrian origin, and a pupil of Theodor Billroth, became a promotor of the X-ray therapy of malignant blastomas in Heidelberg. K. H. Kärcher, who has been head of the Department of Radiotherapy, Vienna University, for the past ten years is a graduate of this famous school.
甚至在世纪之交之前,皮肤科医生利奥波德·弗罗因德在所有已知治疗方法均告失败的情况下,尝试用伦琴于1895年发现的射线治疗一名儿童背部的毛痣。毛发如愿脱落。为了证明电流不是有效因素,弗罗因德去除了电流,并用更长时间治疗毛痣色素沉着毛发过多症的另一部位,以弥补假定的能量损失。结果形成了溃疡。一些知名研究人员怀疑X射线的生物学效应。弗罗因德也开始怀疑自己原来的观点,后来甚至抨击自己的发现。只有罗伯特·金博克经过仔细研究后的发现,才让弗罗因德再次接受他原来的观点。早在第一次世界大战之前就被公认为X射线诊断先驱的吉多·霍尔茨克内希特,在金博克的影响下成功地从事X射线治疗工作。他可被视为世界上最早的放射生物学家之一。奥地利裔、西奥多·比尔罗特的学生文岑茨·策尔尼,成为海德堡恶性母细胞瘤X射线治疗的推动者。过去十年一直担任维也纳大学放射治疗系主任的K. H. 卡彻尔毕业于这所著名学府。